全文获取类型
收费全文 | 177篇 |
免费 | 40篇 |
出版年
2019年 | 1篇 |
2018年 | 2篇 |
2016年 | 5篇 |
2015年 | 6篇 |
2014年 | 17篇 |
2013年 | 18篇 |
2012年 | 14篇 |
2011年 | 15篇 |
2010年 | 16篇 |
2009年 | 9篇 |
2008年 | 12篇 |
2007年 | 10篇 |
2006年 | 5篇 |
2005年 | 11篇 |
2004年 | 9篇 |
2003年 | 5篇 |
2002年 | 7篇 |
2001年 | 5篇 |
2000年 | 4篇 |
1999年 | 6篇 |
1998年 | 5篇 |
1996年 | 1篇 |
1995年 | 5篇 |
1994年 | 1篇 |
1993年 | 3篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 4篇 |
1989年 | 4篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1912年 | 1篇 |
1911年 | 2篇 |
排序方式: 共有217条查询结果,搜索用时 0 毫秒
211.
Rogier Bodewes Siamak Zohari Jesper S. Krog Matthew D. Hall Timm C. Harder Theo M. Bestebroer Marco W. G. van de Bildt Monique I. Spronken Lars E. Larsen Ursula Siebert Peter Wohlsein Christina Puff Frauke Seehusen Wolfgang Baumg?rtner Tero H?rk?nen Saskia L. Smits Sander Herfst Albert D. M. E. Osterhaus Ron A. M. Fouchier Marion P. Koopmans Thijs Kuiken 《Journal of virology》2016,90(9):4269-4277
212.
For many vaccines the amount of antibodies induced has a positive correlation with the likelihood of clinical protection from disease. Mean antibody level is therefore frequently used as a serological surrogate endpoint for vaccine efficacy. In addition, a dichotomous surrogate endpoint is often defined: seroprotection. We explore the relationship between mean antibody level, seroprotection and clinical protection from influenza, using a simple statistical model. The model reveals that the relationship depends not only on the mean but also on the dispersion of the antibody levels, the threshold for clinical protection and the clinical protection curve. The consequences for the interpretation of mean antibody levels and seroprotection rates in terms of clinical protection from influenza are discussed. 相似文献
213.
Bart L. Haagmans Judith M. A. van den Brand Lisette B. Provacia V. Stalin Raj Koert J. Stittelaar Sarah Getu Leon de Waal Theo M. Bestebroer Geert van Amerongen Georges M. G. M. Verjans Ron A. M. Fouchier Saskia L. Smits Thijs Kuiken Albert D. M. E. Osterhaus 《Journal of virology》2015,89(11):6131-6135
The ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to infect small animal species may be restricted given the fact that mice, ferrets, and hamsters were shown to resist MERS-CoV infection. We inoculated rabbits with MERS-CoV. Although virus was detected in the lungs, neither significant histopathological changes nor clinical symptoms were observed. Infectious virus, however, was excreted from the upper respiratory tract, indicating a potential route of MERS-CoV transmission in some animal species. 相似文献
214.
R. D. DRANSFIELD R. BRIGHTWELL J. KIILU M. F. CHAUDHURY D. A. AD ABIE 《Medical and veterinary entomology》1989,3(1):83-95
Seasonal changes in the mean size of tsetse, Glossina pallidipes Austen, as indicated by wing vein length, were monitored during 1983-86 at Nguruman, southwestern Kenya. Changes in size of nulliparous females and wing fray category 1 males were shown to be correlated with the relative humidity 2 months before they were captured. Soil temperature when flies were in the pupal stage had much less effect. Size dependent mortality was demonstrated, with the mean size of flies emerging from pupae significantly less than that of field-caught flies. This mortality must occur at emergence, since there was no evidence of size-dependent mortality once the flies became available to the trap. Size was correlated with density-independent mortality acting on the parent population 2 months previously. It might therefore be possible to use size as an index of the intensity of such mortality. This could be useful when assessing the level of additional mortality required to suppress tsetse populations. 相似文献
215.
216.
217.
V. Stalin Raj Saskia L. Smits Lisette B. Provacia Judith M. A. van den Brand Lidewij Wiersma Werner J. D. Ouwendijk Theo M. Bestebroer Monique I. Spronken Geert van Amerongen Peter J. M. Rottier Ron A. M. Fouchier Berend Jan Bosch Albert D.M.E. Osterhaus Bart L. Haagmans 《Journal of virology》2014,88(3):1834-1838
Middle East respiratory syndrome coronavirus (MERS-CoV) replicates in cells of different species using dipeptidyl peptidase 4 (DPP4) as a functional receptor. Here we show the resistance of ferrets to MERS-CoV infection and inability of ferret DDP4 to bind MERS-CoV. Site-directed mutagenesis of amino acids variable in ferret DPP4 thus revealed the functional human DPP4 virus binding site. Adenosine deaminase (ADA), a DPP4 binding protein, competed for virus binding, acting as a natural antagonist for MERS-CoV infection. 相似文献